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Abstract #3048

Concomitant reduction of glymphatic flow and CBF in mouse model of Alzheimer’s disease

Yunpeng Wang1,2, Zengmin Li1, Kai-Hsiang Chuang1, and Elizabeth J Coulson1

1The University of Queensland, Brisbane, Australia, 2Xi'an Jiaotong University, Shaanxi, China

An impaired glymphatic system has been implicated in the accumulation of toxins such as amyloid beta (Ab) in Alzheimer’s disease. As both glymphatic flow and cerebral blood flow are driven by arterial pressure, we hypothesized that vascular dysfunction represented by reduced cerebral blood flow might contribute to reduced glymphatic flow. Our preliminary results indicate that aged AD mice have both reduced tissue glymphatic flow and reduced cerebral blood flow. Our results suggests that impairment of the glymphatic system in AD may be partly due to impaired cerebrovascular function.

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