An impaired glymphatic system has been implicated in the accumulation of toxins such as amyloid beta (Ab) in Alzheimer’s disease. As both glymphatic flow and cerebral blood flow are driven by arterial pressure, we hypothesized that vascular dysfunction represented by reduced cerebral blood flow might contribute to reduced glymphatic flow. Our preliminary results indicate that aged AD mice have both reduced tissue glymphatic flow and reduced cerebral blood flow. Our results suggests that impairment of the glymphatic system in AD may be partly due to impaired cerebrovascular function.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords