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Abstract #3049

Novel diagnosis index for Alzheimer's disease based on a hybrid sequence of QSM and VBM

Ryota Sato1, Kohsuke Kudo2, Yasuo Kawata3, Niki Udo4, Masaaki Matsushima5, Ichiro Yabe5, Akinori Yamaguchi6, Hisaaki Ochi1, Yoshitaka Bito3, and Toru Shirai1

1Research and Development Group, Hitachi, Ltd., Tokyo, Japan, 2Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Hokkaido, Japan, 3Healthcare Business Unit, Hitachi, Ltd., Tokyo, Japan, 4Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Japan, 5Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan, 6Department of Radiology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan

Voxel-based morphometry (VBM) is widely used to diagnose Alzheimer’s disease (AD). Recently, several studies have showed that quantitative susceptibility mapping (QSM) is also useful for detecting iron deposition in the early stages of AD. In this study, we propose a novel diagnosis index for AD based on both QSM and VBM, which are simultaneously executed by a single scan. The diagnostic performance of the proposed index in regard to AD and MCI patients is compared with that of the conventional VBM-based index. The comparison results show that the proposed index improved diagnostic performance for discriminating MCI patients and control groups.

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