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Abstract #3054

Assessment of dilated perivascular spaces in Alzheimer’s patient and normal aging using 3.0T MR images

Anuja Pradhan1, Martha Singh1, Tafawa Habib1, Mustafa Salimeen1, Xianjun Li1, Miaomiao Wang1, Congcong Liu1, Quqiu Min2, Guanyu Yang3, and Jian Yang1,4

1The first affiliated hospital of Xi'an Jiaotong University, Xi'an, China, 2Department of neurology, The first affiliated hospital of Xi’an Jiaotong University, Xi'an, China, 3Xi’an AccuRad network and technology Co. Ltd., Xi’an, China, Xi'an, China, 4The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiao tong University, Xi’an, Shaanxi 710049, People’s Republic of China, xi'an, China

Assessment of frequently enlarged perivascular space (EPVS) is essential for assessing Alzheimer’s disease (AD) patients. Recently, EPVS density has been found to be related to the early diagnosis of mild cognitive impairment. However, characteristics of the EPVS density in AD patients are not well understood. We evaluated 44 AD patients and 40 controls by assessing the frequency and density of EPVS in quantitative and semi-quantitative methods. The density and frequency of EPVS is higher in AD patients than that in controls. These results suggest that EPVS density could be used as an indicator in the assessment of EPVS in AD.

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