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Abstract #3061

Cerebral venous oxygen saturation variations in Alzheimer's disease complicated with type 2 diabetes patients using susceptibility weighted imaging mapping

Liang Han1, Yanwei Miao1, Junyi Dong1, Xiaoxin Li1, Lizhi Xie 2, Qingwei Song1, and Ailian Liu1

1The First Affiliated Hospital of Dalian Medical University, Dalian, China, 2GE healthcare, Beijing, China

Alzheimer's disease (AD) is a progressive neurodegenerative disease. Epidemiological studies suggest that type 2 diabetes (T2DM) patients are 2 times more likely to develop AD than healthy people. But it is unclear yet why more decreased saturation of blood oxygen and secondary more severe cognitive impairment are present in AD patients with diabetes. Susceptibility weighted imaging (SWI) is widely used in the diagnosis of central nervous system diseases and venous oxygen content is the basis of SWI angiography. As such, this study used SWI mapping to measure the changes of magnetic susceptibility as well as the change of blood oxygen.

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