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Abstract #3062

Multimodal microscopic imaging of iron accumulation and oxidation state in the Alzheimer’s disease hippocampus

Phillip DiGiacomo1, Samuel Webb2, Ed Plowey1, Maged Goubran1, Sherveen Parivash1, Don Born1, Brian Rutt1, and Michael Zeineh1

1Stanford University, Stanford, CA, United States, 2SLAC National Accelerator Laboratory, Menlo Park, CA, United States

Recent evidence suggests that iron, specifically ferrous Fe2+, may produce oxidative stress in Alzheimer’s disease (AD). However, there remains a gap in our understanding of the progression of iron deposition and its oxidation state. Here, we use X-ray fluorescence imaging (XFI), absorption spectroscopy (XAS), and ultra-high resolution ex vivo MRI in human AD specimens to show that elevated levels of iron correlate with disease severity and to demonstrate that elevated levels of ferrous Fe2+ are present in AD, supporting a neuroinflammatory mechanism. This supports the further development of iron-sensitive MRI as an AD biomarker.

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