Abstract #3063

Alzheimer’s disease progressively weakens the face-processing network

Jie Huang¹, Paul Beach², Andrea Bozoki^1,3, and David Zhu^1,4

¹Department of Radiology, Michigan State University, East Lansing, MI, United States, ²Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States, ³Department of Neurology, Michigan State University, East Lansing, MI, United States, ⁴Department of Psychology, Michigan State University, East Lansing, MI, United States

A functional area of unitary pooled activity (FAUPA) is defined as an area in which the temporal variation of the activity is the same across the entire area. Using the signal time course of a task-associated FAUPA may identify the functional network specific for the task, and comparing these task-specific networks between healthy controls and those with neurologic diseases may reveal the relationship between task-specific networks and the disease. A cardinal manifestation of later-stage Alzheimer’s disease (AD) is the progressive disintegration of biographical memory and semantic knowledge. This study found an association of task-specific network disruption with AD severity.

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