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Abstract #3064

Alters of brain iron deposition in Alzheimer's disease patients after cognitive training: A prospective study

Lei Du1, Zifang Zhao2, Lizhi Xie3, and Guolin Ma1

1Department of Radiology, China-Japan Friendship Hospital, Beijing, China, 2Department of Anesthesiology, Peking University First Hospital, Beijing, China, 3GE Healthcare, Beijing, China

The increased iron deposition on brain quantitative susceptibility mapping (QSM) has been proved to be correlated with the decreased cognitive function of Alzheimer’s disease (AD) patients, while cognitive training seems an effective intervention for AD patients in clinic. This study quantifies the change of iron deposition of brain tissues before and after cognitive training and further explores the correlation between the change of iron deposition and the change of mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) scores of mild AD patients. The results indicate that cognitive training can relieve iron deposition in right caudate nucleus (p<0.05), right hippocampus (p<0.01) and bilateral globus pallidus (p<0.05). However, there is no correlation between the change of iron deposition of brain tissues and the change of MMSE and MoCA scores, suggesting that cognitive training might be helpful to diminish disease progression of mild AD patients.

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