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Abstract #3065

Brain connectivity and gray matter volume changes following donepezil treatment in Alzheimer’s disease

Gwang-Won Kim1 and Gwang-Woo Jeong2

1Advanced Institute of Aging Science, Chonnam National University, Gwangju, Korea, Republic of, 2Department of Radiology, Chonnam National University Medical School, Gwangju, Korea, Republic of

Donepezil treatment is associated with improved cognitive performance in patients with Alzheimer’s disease (AD), and its clinical effectiveness has been demonstrated. However, it has been unknown how donepezil treatment influences white matter (WM) connectivity and gray matter (GM) morphology in AD. The purpose of this study was to evaluate the thalamo-cortical white matter connectivity and GM volume after donepezil treatment in patients with AD using probabilistic tractography and voxel-based morphometry (VBM).

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