Donepezil treatment is associated with improved cognitive performance in patients with Alzheimer’s disease (AD), and its clinical effectiveness has been demonstrated. However, it has been unknown how donepezil treatment influences white matter (WM) connectivity and gray matter (GM) morphology in AD. The purpose of this study was to evaluate the thalamo-cortical white matter connectivity and GM volume after donepezil treatment in patients with AD using probabilistic tractography and voxel-based morphometry (VBM).
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