Abstract #3094

Using Glutamate-Weighted Imaging (GluCEST) to Detect Effects of Transcranial Magnetic Stimulation to the Motor Cortex

Abigail T.J. Cember¹, Brian Erickson², Olufunsho Faseyitan³, Apoorva Kelkar², Neil Wilson¹, Ravi Prakash Reddy Nanga¹, Hari Hariharan¹, Ravinder Reddy¹, and John D. Medaglia²

¹Center for Magnetic Resonance and Optical Imaging, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Psychology, Drexel University, Philadelphia, PA, United States, ³Laboratory for Cognition and Neural Stimulation, University of Pennsylvania, Philadelphia, PA, United States

We used glutamate weighted Chemical Exchange Saturation Transfer (GluCEST) imaging to investigate changes in glutamate contrast in the brains of young, healthy adults undergoing transcranial magnetic stimulation (TMS) to the motor cortex. Subjects were scanned to acquire a 2D GluCEST map of a slice which includes the motor cortex, then removed from the scanner and given continuous theta burst stimulation (cTBS). Subjects were scanned again post-stimulation. The resulting images show a trend of decreasing GluCEST contrast in the gray matter of the motor cortex where stimulation was administered. Interestingly, initial GluCEST values appear to predict response to TMS.

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