Abstract #3099

Magnetic resonance spectroscopic imaging of hyperpolarized [1-13C]pyruvate in glioblastoma: a promising tool for investigating tumor metabolism and heterogeneity.

Fulvio Zaccagna¹, James T Grist¹, Mary A. McLean², Charlie J Daniels¹, Frank Riemer¹, Joshua Kaggie¹, Surrin Deen¹, Ramona Woitek¹, Rolf F Schulte ³, Kieren Allinson⁴, Anita Chhabra ⁵, Marie-Christine Laurent¹, Amy J Frary¹, Tomasz Matys¹, Ilse Patterson⁶, Bruno Do Carmo⁶, Stephan Urpsrung ¹, Ian Wilkinson⁷, Bristi Basu⁸, Colin Watts⁹, Stephen J Price⁹, Sarah Jefferies⁸, Jonathan H Gillard¹, Martin J Graves¹, Kevin M Brindle², and Ferdia A Gallagher¹

¹Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ²Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, ³GE Global Research, Munich, Germany, ⁴Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, ⁵Cambridge Cancer Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, ⁶Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, ⁷Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ⁸Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, ⁹Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

Glioblastomas (GBM) are characterized by diffuse infiltration, a high level of intratumoral and intertumoral heterogeneity and a very poor prognosis. Characterising tumor heterogeneity in vivo may improve diagnosis, therapy planning and treatment assessment. Dissolution dynamic nuclear polarization (DNP) is a novel technique that allows dynamic and non-invasive assessment of the metabolism of hyperpolarized (HP) ¹³C-labelled molecules in vivo, such as the preferential exchange of [1-¹³C]pyruvate to [1-¹³C]lactate within tumors (Warburg effect). In this study we explore metabolic reprogramming within glioblastoma (GBM) and its microenvironment using HP [1-¹³C]pyruvate to demonstrate the heterogeneity of pyruvate’s metabolic fate.

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