Glioblastomas (GBM) are characterized by diffuse infiltration, a high level of intratumoral and intertumoral heterogeneity and a very poor prognosis. Characterising tumor heterogeneity in vivo may improve diagnosis, therapy planning and treatment assessment. Dissolution dynamic nuclear polarization (DNP) is a novel technique that allows dynamic and non-invasive assessment of the metabolism of hyperpolarized (HP) 13C-labelled molecules in vivo, such as the preferential exchange of [1-13C]pyruvate to [1-13C]lactate within tumors (Warburg effect). In this study we explore metabolic reprogramming within glioblastoma (GBM) and its microenvironment using HP [1-13C]pyruvate to demonstrate the heterogeneity of pyruvate’s metabolic fate.
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