3D-QALAS Sequence for Brain Volumetry and Cortical Thickness: Comparison with 3D MPRAGE and Scan-Rescan Repeatability
Shohei Fujita1, Akifumi Hagiwara1,2, Masaaki Hori1, Fukunaga Issei1, Christina Andica1, Tomoko Maekawa1,2, Ryusuke Irie1,2, Koji Kamagata1, Kanako K Kumamaru1, Akihiko Wada1, and Shigeki Aoki1
1Department of Radiology, Juntendo University, Tokyo, Japan, 2Department of Radiology, The University of Tokyo, Tokyo, Japan
Previous quantitative synthetic MRI of the brain has been solely performed in 2D. Here, we evaluated the feasibility of the recently developed 3D-QALASsequence for brain cortical thickness and volumetric analysis in healthy volunteers. 3D-QALAS and MPRAGE were performed twice and once, respectively, in the same session at 1.5 T. FreeSurfer and FIRST were used to measure cortical thickness and volume of subcortical structures, respectively. High agreement with MPRAGE and scan-rescan repeatability in both cortical thickness and subcortical structures were shown. 3D-QALAS could be reliably used for measuring cortical thickness and subcortical volumes in most brain regions.
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