Abstract #3119

Comparative analysis of Mean Apparent Propagator (MAP)-MRI and traditional DTI for the diagnosis of hippocampal sclerosis in temporal lobe epilepsy

Keran Ma¹, Jingliang Cheng¹, Xiaonan Zhang¹, Ankang Gao¹, Chengru Song¹, Shaoyu Wang², Xu Yan², and Huiting Zhang²

¹The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²MR Scientific Marketing, Siemens Healthcare, Shanghai, China, Shanghai, China

This study aimed to preliminarily investigate the utility of MAP-MRI parameters in hippocampal sclerosis and compare them with traditional DTI parameters to explore the changes in hippocampal microstructure and understand its pathophysiological mechanisms. The swelling of the hippocampal nerve fiber axon presynaptic terminal can be reflected by MAP-MRI, which greatly assists in the clinical diagnosis of early hippocampal sclerosis. Compared with DTI parameters, DSI parameters showed higher diagnostic efficacy particularly for RTPP and QIV. This study extracted more objective and reproducible parameters of fixed hippocampal sclerosis. More samples are needed for future research.

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