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Abstract #3120

Community-informed connectomics of the thalamo-cortical system in idiopathic generalized epilepsy

Zhengge Wang1, Sara Lariviere2, Qiang Xu1, Reinder Vos de Wael2, Seok-Jun Hong2, Zhongyuan Wang1, Xu Yun1, Bin Zhu1, Neda Bernasconi2, Andrea Bernasconi2, Bing Zhang1, Zhiqiang Zhang1, and Boris C Bernhardt2

1The Affiliated Hospital of Nanjing University Medical School, Nanjing, China, 2McGill University, Montreal, QC, Canada

Idiopathic generalized epilepsy with tonic-clonic seizures (IGE-GTCS) has been associated to the thalamo-cortical circuitry. By quantifying the interplay between macroscale functional communities via resting-state fMRI (rs-fMRI) connectome analysis, we assessed the intrinsic organization of this network and its relation to drug-response. Compared to controls, IGE-GTCS showed a more constrained network embedding of the thalamus, while frontocentral neocortical regions expressed increased functional diversity. Findings remained significant after regressing out thalamic volume and cortical thickness, suggesting independence from structural alterations. We observed more marked network imbalances in drug-resistant compared to seizure-free patients. Our findings suggest a pathoconnectomic mechanism of IGE, centered on diverging changes in cortical and thalamic connectivity. More restricted thalamic connectivity could reflect the tendency to engage in recursive thalamo-cortical loops, which may contribute to hyper-excitability.

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