Positron emission tomography (PET) with fluorodeoxyglucose (FDG) is a widely used approach to help identify putative epileptogenic areas in patients with epilepsy, as part of the epilepsy surgery evaluation. Epileptogenic areas typically show a regional reduction in glucose metabolism. Here we present a dual-calibrated fMRI method (acquiring BOLD and ASL CBF data simultaneously), which permits mapping of the cerebral metabolic rate of oxygen consumption noninvasively across grey matter. In this case report, we demonstrate close agreement between the two methods (dc-fMRI and PET-FDG) in localising a region of cerebral hypometabolism in epilepsy.
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