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Abstract #3125

Mapping brain oxygen metabolism with dual calibrated fMRI in pre-surgical evaluation of epilepsy: a case report comparison with FDG-PET.

Hannah L Chandler1,2, Michael Germuska1, Rhodri Smith2, Patrick Fielding 2, Christopher Marshall2, Khalid Hamandi3, and Richard G Wise1

1Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, 2Wales Research and Diagnostic PET Imaging Centre, Cardiff, United Kingdom, 3Welsh Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, United Kingdom

Positron emission tomography (PET) with fluorodeoxyglucose (FDG) is a widely used approach to help identify putative epileptogenic areas in patients with epilepsy, as part of the epilepsy surgery evaluation. Epileptogenic areas typically show a regional reduction in glucose metabolism. Here we present a dual-calibrated fMRI method (acquiring BOLD and ASL CBF data simultaneously), which permits mapping of the cerebral metabolic rate of oxygen consumption noninvasively across grey matter. In this case report, we demonstrate close agreement between the two methods (dc-fMRI and PET-FDG) in localising a region of cerebral hypometabolism in epilepsy.

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