Cortico-subcortical networks are considered core pathologic substrates for frontal lobe epilepsy with generalized tonic clonic seizures; however, the mechanism is still unknown. This study aims to identify the changes of cortico-subcortical networks by resting-state functional connectivity. 60 patients with frontal lobe epilepsy and healthy controls were enrolled. Bilateral hemispheres were divided into 5 nonoverlapping cortical lobes. Functional connectivity between each cortical lobe and the subcortical regions were calculated, and functional connectivity strength was used to evaluate the interconnectivity. Our results indicate that the decrease connection between prefrontal cortex and subcortical structures suggests it maybe the epicenters of frontal lobe epilepsy.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords