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Abstract #3130

Detection of Focal Cortical Dysplasia via quantitative T1-mapping

Ulrike Nöth1, René-Maxime Gracien2, Michelle Maiworm3, Philipp Reif2, Elke Hattingen3, Susanne Knake4, Marlies Wagner3, and Ralf Deichmann1

1Brain Imaging Center (BIC), Goethe University Frankfurt, Frankfurt am Main, Germany, 2Department of Neurology, University Hospital Frankfurt, Frankfurt am Main, Germany, 3Department of Neuroradiology, University Hospital Frankfurt, Frankfurt am Main, Germany, 4Epilepsy Center Hessen, University Hospital Marburg, Marburg, Germany

Focal cortical dysplasias (FCD) are characterized by an increased cortical thickness and blurred junctions between white (WM) and gray matter (GM). A method for improved FCD detection is proposed, which is only based on quantitative maps of T1 relaxation time. Masks of WM, GM and CSF are derived from the measured T1 values. The local cortical extent (CE) is calculated from the GM mask and the local smoothness (SM) of GM-WM junctions is derived from the T1 gradients. Synthetic double inversion recovery data sets are calculated from the T1 map and further enhanced in areas of increased CE and SM.

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