Abstract #3131

Sub-millimeter blood flow mapping of cortical and hippocampal gray matter

Roy AM Haast¹, Dimo Ivanov², Jordan DeKraker^1,3, Sriranga Kashyap², Shanice EW Janssens², Benedikt A Poser², Ali R Khan^1,3,4, and Kamil Uludag^2,5

¹Centre for Functional Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada, ²Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, ³Brain and Mind Institute, University of Western Ontario, London, ON, Canada, ⁴Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, ⁵Center for Neuroscience Imaging Research, Institute for Basic Science (IBS) & Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

Acquisition of sub-millimeter whole-brain blood flow (CBF) maps was recently demonstrated to be feasible using 7T MRI. Here, we show that such high resolution CBF maps can be used to differentiate cortical regions, in general, and subregions within the hippocampal formation, in particular. We found that higher baseline perfusion was especially present in regions known to be highly myelinated and/or characterized by low quantitative T₁ values. Moreover, these initial results warrant the use of CBF data to improve the interpretability of fMRI activation maps at a finer scale.

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