Three-dimensional reconstruction and dissection of hippocampal fiber pathways with human connectome data

The hippocampus plays a vital role in learning and memory and consists of multiple subfields with distinct functional pathways. Despite many volumetric investigations, in vivo human studies on hippocampal pathways remain scarce. In this study, we show that the Perforant, Alveus/Fimbria, and CA1-Subiculum pathways can consistently reconstructed from the Human Connectome Project (HCP) diffusion MRI dataset aided by automated brain and hippocampal subfield segmentation methods. This demonstrates the feasibility of in vivo mapping of the major hippocampal pathways at 3T, which may lead to new research avenue of the functional pathways of hippocampus in normal and disease states.