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Abstract #3134

Hippocampal subfield segmentation and partial volume effects - reliability assessment

Arturo Cardenas-Blanco1,2, Yi Chen2, Jose-Pedro Valdes-Herrera3, Renat Yakupov1, Hendrik Mattern4, Alessandro Sciarra4, David Berron5, Anne Maass1, Oliver Speck1,4,6,7, and Emrah Duezel1,2

1German center for neurodegenerative diseases (DZNE), Magdeburg, Germany, 2Institute of cognitive neurology and dementia research, Magdeburg, Germany, 3Aging & Cognition Research Group, German center for neurodegenerative diseases (DZNE), Magdeburg, Germany, 4Department of Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany, 5Department of clinical sciences, Clinical memory research unit, Malmoe, Sweden, 6Center for Behavioral Brain Sciences, Magdeburg, Germany, 7Leibniz Institute for Neurobiology, Magdeburg, Germany

The hippocampus is involved in a variety of cognitive and functional tasks. Research groups rely on volumetric segmentations to assess: the integrity of the HC and its subfields as well as their involvement in cognitive tasks. Unfortunately, due to its size and location, most studies use non-isotropic T2-weighted images to segment the HC. The aim of this project is to determine whether partial volume effects due to T2-weighted slice angulation and non-isotropic resolution have an impact in the segmentation process. The results indicate that both, angulation and non-isotropic acquisition have a significant impact in specific subfields.

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