Within the nucleus accumbens(NAC) there is a clear distinction between the shell and core portions. Growing evidences have supported that the NAC, especially its shell portion has been involved in epileptogenesis. However relevant studies on vivo human brains are quite limited. in this study, we investigated Left mTLE related function connectivity changes of NAC subregions . Our result indicated an decrease in FC between left shell and right frontal area and an increase FC between right shell and left temporal area. But no significant FC changes appear on core, which suggest that shell portion play important roles on mTLE.