Abstract #3138

Dilatation of Virchow-Robin Spaces is An Acute Phase Response in Children with Epileptic Seizure

Tafawa Habib¹, Mustafa Salimeen¹, Xianjun Li¹, Guanyu Yang², Anuja Pradhan¹, Martha Singh¹, Lu Gao¹, Miaomiao Wang¹, Congcong Liu¹, and Jian Yang^1,3

¹Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China, ²Xi’an AccuRad Network and Technology Co.Ltd., Xi’an, China, ³Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiao tong University, Xi’an, China

Dysfunction of Virchow -Robin spaces (VRS) has become an exciting avenue of research for the exploration of the pathophysiology involving CNS neurodegenerative and neuroinflammatory disorders. To investigate the pathophysiological link of the dilated VRS (dVRS) in children with epilepsy, we conducted semiquantitative and quantitative assessment of dVRS visible on standard 3.0T magnetic resonance imaging (MRI) in children with clinical history of symptomatic generalized tonic clonic, clonic or myoclonic seizures. Our results revealed the tendency of increased number of dVRS in the early phase following epileptic seizure, suggesting that dilated VRS might be related to the cascade of immune response during epileptic seizures.

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