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Abstract #3140

Thalamic energy dysregulation drives microstructural changes of thalamo-cortical projections in multiple sclerosis

Vito AG RICIGLIANO1, Matteo Tonietto1, Raffaele Palladino2,3, Emilie Poirion1, Francesca Branzoli1,4, Geraldine Bera1, Elisabeth Maillart5, Bruno Stankoff1,6, and Benedetta Bodini1,6

1Brain and Spinal Cord Institute (ICM), Paris, France, 2Department of Primary Care and Public Health, School of Public Health, Imperial College of London, London, United Kingdom, 3Department of Public Health, University “Federico II” of Naples, Naples, Italy, 4Neuroimaging Research Centre - ICM, Paris, France, 5Hopital De La Pitie Salpetriere, Paris, France, 6APHP, St Antoine Hospital, Neurology Department, Paris, France

Our objective was to investigate whether thalamic energy alterations in multiple sclerosis (MS) are associated with microstructural degeneration of thalamo-cortical tracts. In 17 patients and 13 healthy controls (HCs), the apparent diffusion coefficient of creatine-phosphocreatine ADC(tCr) in the thalami, reflecting energy dysregulation, was evaluated with diffusion-weighted magnetic resonance spectroscopy. Integrity of thalamo-cortical and non-thalamic tracts was evaluated by measuring mean diffusivity (MD) with standard diffusion weighted imaging. In patients but not in HCs, lower thalamic ADC(tCr) was associated with higher MD of thalamo-cortical tracts only, suggesting that thalamic energy dysfunction may induce the selective anterograde degeneration of thalamo-cortical networks.

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