Abstract #3141

In-vivo mapping of thalamic pathological mechanisms in pediatric patients with MS

Loredana Storelli¹, Ermelinda De Meo^1,2, Lucia Moiola², Maria Pia Amato³, Angelo Ghezzi⁴, Pierangelo Veggiotti^5,6, Ruggero Capra⁷, Maria A. Rocca^1,2, and Massimo Filippi^1,2

¹Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ²Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ³Department NEUROFARBA, Section Neurosciences, University of Florence, Florence, Italy, ⁴Multiple Sclerosis Center, Ospedale di Gallarate, Gallarate, Italy, ⁵Department of Child Neurology and Psychiatry, C. Mondino National Neurological Institute, Pavia, Italy, ⁶Brain and Behaviour Department, University of Pavia, Pavia, Italy, ⁷Multiple Sclerosis Center, Spedali Civili of Brescia, Brescia, Italy

Despite widely recognized in pediatric population with multiple sclerosis (MS), the pathogenesis of thalamic damage remains largely unknown. This study was performed to explore the microstructural abnormalities within this structure through the use of quantitative MRI metrics (diffusion tensor, T1/T2-weighted ratio) considering the two different thalamic interfaces (cerebrospinal fluid/thalamus and thalamus/white matter) as sites of two different pathogenic processes: the first one accounting for cerebrospinal fluid-mediated factor damage and the second one for diffuse neurodegenerative damage. The study demonstrated an heterogeneous pathogenesis for thalamic damage since the beginning of the disease.

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