The purpose of this study is to characterize multi-scale cerebral perfusion in patients with multiple sclerosis (MS) using an advanced spin- and gradient-echo (SAGE) dynamic susceptibility contrast (DSC) MRI method. SAGE DSC-MRI provides macro- and micro-vascular perfusion, permeability, and other vascular parameters. We have acquired SAGE DSC-MRI data in 24 patients, along with a quality of life metric. Preliminary analysis of the first five patients demonstrated reduced perfusion in patients with lower quality of life scores than patients with higher quality of life scores. Work is ongoing to characterize the full set of SAGE-based hemodynamic metrics in these patients.
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