Meeting Banner
Abstract #3146

Quantification of cerebral grey matter vascular and metabolic function in multiple sclerosis using dual-calibrated fMRI.

Hannah L Chandler1, Rachael Stickland1, Mike Germuska1, Eleonora Patitucci 1, Catherine Foster2, Sharmila Khot1, Neeraj Saxena1, Valentina Tomassini3,4, and Richard G Wise1

1Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom, 2Department of Physics, Concordia University, Montreal, QC, Canada, 3Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom, 4Helen Durham Centre for Neuroinflammation, University Hospital of Wales, Cardiff, United Kingdom

Dual-calibrated fMRI (dc-fMRI) relies on the simultaneous acquisition of BOLD and ASL during a respiratory challenge to quantitatively map cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2), oxygen extraction fraction (OEF), cerebrovascular reactivity (CVR) and effective oxygen diffusivity (D). Here, we use this method to investigate alterations in brain physiology in patients with multiple sclerosis (and matched healthy participants), demonstrating significant reductions in CBF and CMRO2 per unit of remaining grey matter in patients. We suggest that this method not only provides novel markers of tissue dysfunction, it also extends the methodological armamentarium for non-invasive investigation of brain pathophysiology in disease.

This abstract and the presentation materials are available to members only; a login is required.

Join Here