Abstract #3159

Brain volume measurements in multiple sclerosis patients: a novel combination approach for routine clinical assessment in MS PATHS

Adrian Tsang¹, Yu-Chen Su¹, Rodrigo D Perea¹, Ricardo Corredor-Jerez^2,3,4, Mário João Fartaria^2,3,4, Till Huelnhagen^2,3,4, Veronica Ravano⁴, Bénédicte Maréchal^2,3,4, Tobias Kober^2,3,4, Robert A Bermel⁵, Stephen E Jones⁵, Izlem Izbudak⁶, Yvonne W Lui⁷, Lauren Krupp⁷, Ellen M Mowry⁶, James R Williams¹, Rick Rudick¹, and Elizabeth Fisher¹

¹Biogen, Cambridge, MA, United States, ²LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ³Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, ⁴Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁵Cleveland Clinic, Cleveland, OH, United States, ⁶Johns Hopkins University, Baltimore, MD, United States, ⁷New York University, New York, NY, United States

Highly precise measurements from fully automated techniques are required to quantify brain atrophy in individual multiple sclerosis (MS) patients. We developed a novel approach to reliably estimate brain atrophy in MS that combines two techniques applied to different image contrasts and incorporates inter-scanner calibrations. We validated this approach using data acquired in a scan-rescan study. Mean coefficient of variation (CV) for the new brain parenchymal fraction measurement was 0.18%, which was lower than the CV attained for the individual techniques. This new metric will next be integrated into the radiology workflow in MS PATHS institutions for further testing.

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