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Abstract #3159

Brain volume measurements in multiple sclerosis patients: a novel combination approach for routine clinical assessment in MS PATHS

Adrian Tsang1, Yu-Chen Su1, Rodrigo D Perea1, Ricardo Corredor-Jerez2,3,4, Mário João Fartaria2,3,4, Till Huelnhagen2,3,4, Veronica Ravano4, Bénédicte Maréchal2,3,4, Tobias Kober2,3,4, Robert A Bermel5, Stephen E Jones5, Izlem Izbudak6, Yvonne W Lui7, Lauren Krupp7, Ellen M Mowry6, James R Williams1, Rick Rudick1, and Elizabeth Fisher1

1Biogen, Cambridge, MA, United States, 2LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 3Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 5Cleveland Clinic, Cleveland, OH, United States, 6Johns Hopkins University, Baltimore, MD, United States, 7New York University, New York, NY, United States

Highly precise measurements from fully automated techniques are required to quantify brain atrophy in individual multiple sclerosis (MS) patients. We developed a novel approach to reliably estimate brain atrophy in MS that combines two techniques applied to different image contrasts and incorporates inter-scanner calibrations. We validated this approach using data acquired in a scan-rescan study. Mean coefficient of variation (CV) for the new brain parenchymal fraction measurement was 0.18%, which was lower than the CV attained for the individual techniques. This new metric will next be integrated into the radiology workflow in MS PATHS institutions for further testing.

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