Brain ventricle volumes (VV) increased sharply during initial disease in the experimental autoimmune encephalomyelitis model of multiple sclerosis (MS), normalizing upon clinical remission. A cohort of MS patients with 13 monthly MRI scans over one year showed significantly greater VV volatility than healthy controls. Most patients showed VV contractions greater than the ±6% range of variation in healthy controls, and these patients had significantly lower disease severity compared to non-contracting patients. For some patients, the time series of changes in VV showed significant cross-correlations with other MRI and clinical parameters, suggesting that VV variations reflected disease processes related to inflammation.
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