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Abstract #3160

Transient enlargement of brain ventricles during Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Jason Michael Millward1, Laura Böhmert 1, Paula Ramos Delgado1, Henning Reimann1, Joao Periquito1, Antje Els1, Alina Smorodchenko2, Michael Scheel3, Judith Belmann-Strobl3,4, Carmen Infante-Duarte5, Friedemann Paul3,4, Thoralf Niendorf1,4, Andreas Pohlmann1, and Sonia Waiczies1

1Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine, Berlin, Germany, 2Institute for Vegetative Anatomy, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, 5Institute for Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

Brain ventricle volumes (VV) increased sharply during initial disease in the experimental autoimmune encephalomyelitis model of multiple sclerosis (MS), normalizing upon clinical remission. A cohort of MS patients with 13 monthly MRI scans over one year showed significantly greater VV volatility than healthy controls. Most patients showed VV contractions greater than the ±6% range of variation in healthy controls, and these patients had significantly lower disease severity compared to non-contracting patients. For some patients, the time series of changes in VV showed significant cross-correlations with other MRI and clinical parameters, suggesting that VV variations reflected disease processes related to inflammation.

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