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Abstract #3162

Spatial distribution of multiple sclerosis lesions along the brain and spinal motor tracts and correlation with functional deficits

Anne Kerbrat1,2, Charley Gros1, Atef Badji1, Elise Bannier3,4, Francesca Galassi4, Benoit Combès4, Pierre Labauge5, Xavier Ayrignac5, Clarisse Carra Dallière5, Frederic Pinna5, Benjamin De Leener6, Dominique Eden1, Josefina Maranzano6, Ren Zhuoquiong7, Tobias Granberg8, Leszek Stawiarz8, Jan Hillert8, Russell Ouellette8, Jason Talbott9, Yasuhiko Tachibana10, Masaaki Hori11, Kouhei Kamiya11, Lydia Chougar12, Jennifer Lefeuvre13, Daniel Reich13, Govind Nair 13, Paola Valsasina14, Maria Rocca14, Massimo Filippi14, Renxin Chu15, Rohit Bakshi15, Gilles Edan2, and Julien Cohen-Adad1,16

1NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Neurology, CHU de Rennes, Rennes, France, 3Radiology, CHU de Rennes, Rennes, France, 4Univ Rennes, Inria, CNRS, Inserm, IRISA UMR 6074, Visages U1128, Rennes, France, 5CHU Montpellier, Montpellier, France, 6McConnell Brain Imaging Center, Montreal neurological institute, Montreal, QC, Canada, 7Xuanwu Hospital, Beijing, China, 8Karolinska Institutet, Stockholm, Sweden, 9Zuckerberg San Francisco General Hospital, University of California, San Francisco, CA, United States, 10National Institute of Radiological Sciences, Chiba, Japan, 11Juntendo University Hospital, Tokyo, Japan, 12Hopital Cochin, Paris, France, 13National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, 14Neuroimaging Research Unit, INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 15Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 16Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, QC, Canada

We describe the spatial distribution of multiple sclerosis (MS) lesions in the corticospinal tracts (CST), from the cortex to the lower cervical cord, using an open-source automated pipeline. We confirm the high frequency of CST focal damage in MS patients from the first year of relapsing-remitting MS and identify areas of predilection for MS lesions along the CST in the cervical spinal cord. At baseline, no significant correlation was observed between brain or spinal cord CST lesion volume fraction and physical disability scores. However, the baseline spinal cord CST lesion volume fraction correlated with the EDSS at 2 years.

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