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Abstract #3163

Investigating the contribution of interhemispheric disconnection to disability and fatigue in Progressive Multiple Sclerosis.

Maria Petracca1, Matteo Battocchio 2, Simona Schiavi2,3, Mohamed Mounir El Mendili1, Lazar Fleysher1, Alessandro Daducci2, and Matilde Inglese1,3

1Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2University of Verona, Verona, Italy, 3University of Genoa/IRCCS AOU San Martino-IST, Genova, Italy

We explored the presence and clinical impact of interhemispheric disconnection in progressive multiple sclerosis (PMS) through a tractography-based approach, quantifying the number of streamlines passing through callosal subregions. In PMS, we identified a reduced number of streamlines in the splenium and the anterior portion of the corpus callosum (CC) body. Patients with primary and secondary progressive phenotype presented different patterns of CC involvement. The reduced number of streamlines in central and anterior CC was related to motor disability and fatigue, while loss of the integrity in the posterior portion of CC was the main feature of cognitively impaired patients.

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