Abstract #3164

Vascular disease risk factors in multiple sclerosis is associated with reduced cerebral metabolic activity

Manoj K Sammi¹, Ian Tagge¹, Dennis Bourdette^2,3, Allison Fryman^2,3, William D Rooney¹, and Vijayshree Yadav^2,3

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Department of Neurology, Oregon Health & Science University, Portland, OR, United States, ³VA Portland Health Care System, Portland, OR, United States

Reduced cerebral metabolic activity is observed with increased vascular disease risk factors like hyperlipidemia, hypertension, obesity, diabetes, and heart disease. High resolution MR techniques are used to measure and characterize capillary water flux and water permeability surface product as potential surrogates of brain metabolic activity.

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