Meeting Banner
Abstract #3169

Reference Regions for Computing Relative Cerebral Blood Flow in Mild Cognitive Impairment

Sudipto Dolui1, Zhengjun Li1, Ilya Nasrallah1, David A. Wolk2, and John A. Detre1,2

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

Alzheimer’s disease (AD) is characterized by reduced cerebral blood flow (CBF) both globally and in AD specific regions, however there is considerable CBF variability even in healthy population. Relative CBF using mean CBF in AD-spared regions as reference removes this variability and can provide higher sensitivity and specificity for regional changes. We compared the effects of using different reference regions in discriminating patients with amnestic mild cognitive impairment (aMCI) and elderly controls using two different arterial spin labeling acquisitions. Putamen and primary motor cortex were most spared in the aMCI cohort and provided best patient-diagnosis when used as reference regions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here