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Abstract #3170

Does obesity cause limbic neuroglia changes that may precede Alzheimer's disease? An MRI causal analysis investigation using quantitative magnetisation transfer

Fabrizio Fasano1, John Evans2, Cyril Charron2, Derek Jones2, and Claudia Metzler-Baddeley2

1Siemens Healthcare Ltd, Frimley, Camberley, United Kingdom, 2CUBRIC, Cardiff University, Cardiff, United Kingdom

By a causal analysis approach, we investigated the effect that an “intervention” on healthy population weight would produce on hippocampus macromolecular exchange rates. The quantitative magnetisation transfer index forward exchange rate (kf) is recognised to be lowered by myelin/axonal membrane loss and neuroinflammation. We found that, especially in over 56 years aged male subjects, forcing the weight to stay below the overweight threshold (waist-to-hip ratio 0.9) may dramatically reduce low macromolecular exchange rate occurrences in the population.

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