Intracranial artery features measured from 3D magnetic resonance angiography (MRA) may provide new biomarkers for detecting dementia. Quantitative morphometry and intensity features using iCafe analysis of MRA was compared between cognitively normal and abnormal subjects. We found significantly lower total artery length (p=0.0046), distal artery length (p=0.0043), number of branches (p=0.0038) and average order (p=0.0250) in the cognitively abnormal group. These results suggest reduced vascularity for dementia subjects. iCafe is a promising tool to quantitatively characterize intracranial vascular structures for dementia research.
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