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Abstract #3172

Neuropathologic Correlates of Enlarged Perivascular Spaces in a Community Cohort of Older Adults

Carles Javierre Petit1, Ashish A. Tamhane2, Arnold M. Evia1, Nazanin Makkinejad1, David A. Bennett2, Julie A. Schneider2, and Konstantinos Arfanakis1

1Illinois Institute of Technology, Chicago, IL, United States, 2Rush University Medical Center, Chicago, IL, United States

Perivascular spaces are fluid-filled spaces surrounding blood vessels as they penetrate the brain, forming a brain fluid drainage system that facilitates interstitial fluid exchange and clearance of waste products. Enlargement of perivascular spaces is common in aging, and literature has linked enlarged perivascular spaces (EPVS) to increased risk of stroke, lower cognitive function, and vascular dementia. The links of EPVS burden to age-related neuropathologies have not yet been thoroughly investigated. Therefore, the purpose of this work was to assess the neuropathologic correlates of EPVS by combining ex-vivo MRI and pathology data in a large community cohort of 625 older adults.

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