We used glutamate weighted Chemical Exchange Saturation Transfer (GluCEST) imaging to investigate changes in glutamate concentrations in the brains of older adults. These are preliminary findings representing the data from subjects presenting with Mild Cognitive Impairment (MCI) (n=5) and similarly-aged healthy controls (n=5). In this cohort, we observed a trend of decreasing GluCEST contrast in multiple regions of the brain of MCI subjects when compared to control subjects. Especially interesting is the apparent global decrease in GluCEST contrast throughout the white matter of the MCI subjects.
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