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Abstract #3173

Glutamate Weighted Imaging (GluCEST) as a Biomarker of Cognitive Function: Preliminary Findings from GluCEST MRI in Older Adults

Abigail T.J. Cember1, Ravi Prakash Reddy Nanga1, Sandhitsu Das2, Neil E. Wilson1, Deepa Thakuri1, David Wolk2, John Detre1, and Ravinder Reddy1

1Center for Magnetic Resonance and Optical Imaging, University of Pennsylvania, Philadelphia, PA, United States, 2Penn Memory Center, University of Pennsylvania, Philadelphia, PA, United States

We used glutamate weighted Chemical Exchange Saturation Transfer (GluCEST) imaging to investigate changes in glutamate concentrations in the brains of older adults. These are preliminary findings representing the data from subjects presenting with Mild Cognitive Impairment (MCI) (n=5) and similarly-aged healthy controls (n=5). In this cohort, we observed a trend of decreasing GluCEST contrast in multiple regions of the brain of MCI subjects when compared to control subjects. Especially interesting is the apparent global decrease in GluCEST contrast throughout the white matter of the MCI subjects.

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