In patients with mild cognitive impairment from ADNI MRI database, joint analyses of FLAIR and diffusion-tensor MRI (DTI) find significant positive correlation between periventricular white matter lesion (PVWML) and ventricle volumes; and negative correlation between PVWML and grey matter thickness of four cortical regions. Furthermore, significant correlations were found between PVWML and DTI measures (FA, MD, AD and RD) within the WM in close proximity to four cortical regions, indicating the degenerative changes in remote subcortical WM regions that can be quantitatively evaluated with DTI. However, such correlations were not found in either normal controls or patients with AD.
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