Abstract #3180

Quantification of neuronal loss related to cognitive impairment in mild Alzheimer disease in hippocampal subfields using quantitative gradient recalled echo (qGRE) MRI

Satya VVN Kothapalli¹, Tammie L Benzinger^1,2, Jason Hassenstab^2,3, Manu S Goyal^1,3, John C Morris^2,3, and Dmitriy A Yablonskiy¹

¹Department of Radiology, Washington University in Saint Louis, Saint Louis, MO, United States, ²Knight Alzheimer’s Disease Research Center, Washington University in St. Louis, Saint Louis, MO, United States, ³Department of Neurology, Washington University in St. Louis, Saint Louis, MO, United States

Damage of hippocampus leading to cognitive decline is one of the major hallmarks of Alzheimer disease (AD). Differentiating neuronal loss in hippocampal subfields is important as they control different biological functions. In this study, we used MRI-based qGRE technique to evaluate neuronal content (in the remaining after atrophy tissue) of hippocampal subfields in a well-characterized cohort of human subjects recruited from Knight ADRC. Our results showed pronounced left/right asymmetry in the pattern of neuronal damage in mild AD and a significantly stronger (compared to atrophy) correlation between neuronal loss in the remaining tissue of hippocampal subfields and cognitive tests.

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