This
study aims to investigate the functional topological properties in T2DM with
and without impairment, and characterize its relationships with clinical
measurements. Forty-four T2DM patients were divided into two sub-groups
(impaired and normal cognition), together with healthy controls, were imaged at
a 3T scanner. We found no significant intergroup difference in global
measurements among the three group. However, increased or decreased nodal
efficiency was detected in some important brain regions. Altered nodal
efficiency in FFG and ITG correlated with glycosylated hemoglobinA1c and neuropsychological
assessments. The resting-state functional topological properties research shows
potential feasibility in characterizing intrinsic alterations of diabetic
encephalopathy.
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