Meeting Banner
Abstract #3185

Progressive Alterations in Resting-State Regional Homogeneity in Type 2 Diabetes with and without Mild Cognitive Impairment

Ying Xiong1, Qiang Zhang2, and Wenzhen Zhu1

1Department of Radiology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, China, 2Department of Neurology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, China

This study aims to detailly investigate the alterations in spontaneous brain activity in T2DM patients with and without MCI and characterize its relationships with clinical measurements. Forty-four T2DM patients were divided into two sub-groups(impaired and normal cognition), together with 25 healthy controls, were scanned at 3Tscanner. T2DM patients with normal cognition had increased regional-homogeneity in many important brain regions than controls. Those with MCI exhibited regional-homogeneity in right inferior frontal gyrus in a further step. Increased regional-homogeneity correlated with neuropsychological assessment, glycosylated-hemoglobinA1c and disease duration. Rs-fMRI can be an appropriate approach for studying the alteration in spontaneous brain activity in diabetes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here