This
study aims to detailly investigate the alterations in spontaneous brain
activity in T2DM patients with and without MCI and characterize its
relationships with clinical measurements. Forty-four T2DM patients were divided
into two sub-groups(impaired and normal cognition), together with 25 healthy
controls, were scanned at 3Tscanner. T2DM patients with normal cognition had increased
regional-homogeneity in many important brain
regions than controls. Those with MCI exhibited regional-homogeneity in right
inferior frontal gyrus in a further step. Increased
regional-homogeneity correlated with neuropsychological assessment, glycosylated-hemoglobinA1c
and disease duration. Rs-fMRI can be an appropriate approach for studying the alteration
in spontaneous brain activity in diabetes.
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