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Abstract #3196

In vivo longitudinal 1H MRS study of hippocampal, cereberal and striatal metabolic changes in the developing brain using an animal model of Chronic Hepatic Encephalopathy

Dunja Simicic1, Katarzyna Pierzchala2, Veronika Rackayova2, Olivier Braissant 3, Stefanita-Octavian Mitrea2, Dario Sessa4, Valerie McLin4, and Cristina Cudalbu Ramona2

1LIFMET, CIBM, EPFL, Lausanne, Switzerland, 2CIBM, EPFL, Lausanne, Switzerland, 3Neurometabolic Unit, Service of Clinical Chemistry, University Hospital of Lausanne, Lausanne, Switzerland, 4Swiss Center for Liver Disease in Children, University Hospitals Geneva, Geneva, Switzerland

Chronic hepatic encephalopathy (CHE) is a severe neuropsychiatric disorder associated with chronic liver disease (CLD). For children, the impairment of neurocognitive functions as a consequence of CLD seems to be irreversible. We aimed to investigate longitudinally, using in-vivo 1H-MRS, differences in metabolic changes between hippocampus, cerebellum and striatum of a developing brain in a rat model of CHE. We showed the most pronounced changes in metabolites in cerebellum, suggesting its increased vulnerability. Further delineation of regional changes in the brain in response to CLD may help elucidate the molecular and regional origins of neuromotor and neurocognitive changes associated with CLD.

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