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Abstract #3205

Performance of sodium, ultrafast diffusion, and MPIO stem cell tracking MRI classification of sub-acute ischemic stroke recovery at 21.1T

Avigdor Leftin1,2,3, Jens Rosenberg4, Xuegang Yuan5, Teng Ma5, Samuel Colles Grant4,5, and Lucio Frydman2,4

1Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 3Radiology, Stony Brook Medicine, Stony Brook, NY, United States, 4National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 5Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States

MRI leverages multiple modes of contrast to characterize stroke. Acute phase stroke detection has focused on multiparametric MRI contrasts such as T2-weighting (T2w), apparent diffusion coefficient (ADC), and sodium level. Evaluation of these contrasts with theranostic cell tracking during the subacute recovery phase at ultrahigh field has not been investigated to a similar extent. Here multiparametric MRI evaluation of ADC, 23Na, and MPIO stem cell tracking in a rodent MCAO model at 21.1T was used to determine parametric correlations and receiver operator performance. Differential parametric time-dependence and sensitivities are observed that inform future high-and low field studies of stroke recovery.

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