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Abstract #3206

Contrast-enhanced MR microangiography of cortical vascular remodeling after unilateral internal carotid artery occlusion in the mouse

Philipp Boehm-Sturm1,2, Till de Bortoli3,4, Stefan Paul Koch1,2, Melina Nieminen3, Susanne Mueller1,2, Giovanna Diletta Ielacqua5, Jan Klohs5, Ulrich Dirnagl1, Peter Vajkoczy3, and Nils Hecht3

1Department of Experimental Neurology and Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany, 2Cluster of Excellence NeuroCure and Charité Core Facility 7T Experimental MRIs, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Department of Neurosurgery and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Charité Comprehensive Cancer Center, Charité – Universitätsmedizin Berlin, Berlin, Germany, 5Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland

Collateral flow is an important, yet poorly understood compensatory mechanism in response to brain hypoperfusion. Unilateral internal carotid artery occlusion in the mouse is a model to study collateral growth of penetrating arterioles. We hypothesized that this process could be assessed in vivo by high resolution MR microangiography with iron oxide nanoparticles. Since our MR vessel density measurements contradicted previous histological findings we established atlas tools to validate angiograms with microscopy on vessel-stained tissue slices or with whole brain serial two photon microscopy.

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