In the present study, in
vivo MR spectroscopy was employed to investigate the neuro-metabolites
changes of dorsolateral prefrontal cortex (DLPFC) and
ventrolateral prefrontal cortex (VLPFC) in adult macaques with neonatal
hippocampus lesion (Neo-H). Significant
metabolite changes were seen in the right DLPFC of
the Neo-H monkeys but not in the VLPFC, and significantly correlated
with the working memory scores. Also, lateralization of the cerebral metabolite
changes was observed. The results suggest that the neuro-metabolites changes in
DLPFC and VLPFC of adult monkeys resulted from early insult to the hippocampus
and the effect is mainly seen in the right hemisphere.
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