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Abstract #3208

Investigation of cerebral metabolite changes in the dorsolateral and ventrolateral prefrontal cortex of adult macaques with neonatal hippocampal lesions

Chun-Xia Li1, Christa Payne2, Xiaoping Hu3, Jocelyne Bachevalier2,4, and Xiaodong Zhang1,4

1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2Department of Psychology and Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 3Department of Bioengineering, University of California, Riverside, CA, United States, 4Division of Neuropharmacology and Neurologic Disease, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States

In the present study, in vivo MR spectroscopy was employed to investigate the neuro-metabolites changes of dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) in adult macaques with neonatal hippocampus lesion (Neo-H). Significant metabolite changes were seen in the right DLPFC of the Neo-H monkeys but not in the VLPFC, and significantly correlated with the working memory scores. Also, lateralization of the cerebral metabolite changes was observed. The results suggest that the neuro-metabolites changes in DLPFC and VLPFC of adult monkeys resulted from early insult to the hippocampus and the effect is mainly seen in the right hemisphere.

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