Abstract #3208

Investigation of cerebral metabolite changes in the dorsolateral and ventrolateral prefrontal cortex of adult macaques with neonatal hippocampal lesions

Chun-Xia Li¹, Christa Payne², Xiaoping Hu³, Jocelyne Bachevalier^2,4, and Xiaodong Zhang^1,4

¹Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ²Department of Psychology and Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ³Department of Bioengineering, University of California, Riverside, CA, United States, ⁴Division of Neuropharmacology and Neurologic Disease, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States

In the present study, in vivo MR spectroscopy was employed to investigate the neuro-metabolites changes of dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) in adult macaques with neonatal hippocampus lesion (Neo-H). Significant metabolite changes were seen in the right DLPFC of the Neo-H monkeys but not in the VLPFC, and significantly correlated with the working memory scores. Also, lateralization of the cerebral metabolite changes was observed. The results suggest that the neuro-metabolites changes in DLPFC and VLPFC of adult monkeys resulted from early insult to the hippocampus and the effect is mainly seen in the right hemisphere.

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