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Abstract #3209

Reduced cerebral blood flow measured in the EAE mouse model of multiple sclerosis using perfusion MRI

Taelor Evans1,2,3,4, A. Max Hamilton1,2,3,4, Erin Stephenson2,3, V. Wee Yong2,3, and Jeff F. Dunn1,2,3,4

1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 3Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada, 4Experimental Imaging Center, University of Calgary, Calgary, AB, Canada

Multiple sclerosis (MS) is a chronic neurological disease involving inflammation. Brain hypoxia, or low brain oxygenation, in MS is an emerging field of study. It has been shown that some MS patients have reduced cerebral blood flow (CBF), but the mechanism is unclear. Experimental autoimmune encephalomyelitis (EAE) is a mouse model used to study inflammation-associated neurodegeneration. Using perfusion MRI and immunohistochemistry, we demonstrated that CBF reduction in EAE may be due to cerebral blood vessel occlusion in response to systemic inflammation. CBF reduction, coupled with brain inflammation, is a likely cause of hypoxia in MS.

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