Abstract #3210

Using a multimodal near-infrared spectroscopy and MRI system to quantify gray matter metabolic rate for oxygen: A hypothermia validation study

Mada Hashem^1,2,3,4,5, Ying Wu^2,3,4,5, and Jeff F. Dunn^1,2,3,4,5

¹Biomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada, ²Department of Radiology, University of Calgary, Calgary, AB, Canada, ³Hotchkiss Brain Istitute, University of Calgary, Calgary, AB, Canada, ⁴Experimental Imaging Centre, University of Calgary, Calgary, AB, Canada, ⁵Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Non-invasive quantitative imaging of cerebral oxygen metabolism (CMRO₂) in mice is crucial to understand the role of oxidative metabolism in neurological diseases. We are developing a multimodal method combining near-infrared spectroscopy and high-field MRI to non-invasively study oxygen delivery and consumption in the cortex of mouse models of neurological disease. In this study, the feasibility of the NIRS-MRI technique to detect changes in CMRO₂ in the mouse brain was assessed using a mild hypothermia, known to reduce metabolic rate. A decrease of 23% in CBF and 46% in CMRO₂ was observed, which is consistent with previously published values.

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