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Abstract #3211

MRI Discriminates between the Aged and Aged Diabetic Brain of Rats

Guangliang Ding1, Michael Chopp1,2, Lian Li1, Li Zhang1, Esmaeil Davood-Bojd1, Qingjiang Li1, Min Wei1, Zhenggang Zhang1, and Quan Jiang1,2

1Henry Ford Hospital, Detroit, MI, United States, 2Oakland University, Rochester, MI, United States

Aging and diabetes both affect brain structure and physiology. To distinguish changes in brain induced by normal aging from diabetes in the aging brain, MRI measurements were performed on three groups of young, aged non-diabetic and correspondingly aged diabetic rats. MRI measurements, i.e., T1, T2, CBF, CE-T1WI, MD, FA, MK and Entropy were performed. Our data indicate that select MRI metrics FA of white and grey matter, and combination of T1 and T2 of grey matter are able to discriminate cerebral changes caused by aging and age-equivalent diabetes.

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