Aging and diabetes both affect brain structure and physiology. To distinguish changes in brain induced by normal aging from diabetes in the aging brain, MRI measurements were performed on three groups of young, aged non-diabetic and correspondingly aged diabetic rats. MRI measurements, i.e., T1, T2, CBF, CE-T1WI, MD, FA, MK and Entropy were performed. Our data indicate that select MRI metrics FA of white and grey matter, and combination of T1 and T2 of grey matter are able to discriminate cerebral changes caused by aging and age-equivalent diabetes.
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