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Abstract #3212

Longitudinal monitoring of brain glutamate levels using gluCEST in a rat model of Huntington’s disease

Julien Flament1, Jérémy Pépin1, Julien Valette1, and Emmanuel Brouillet1

1MIRCen, CEA, Fontenay-aux-Roses, France

Huntington’s disease (HD) is an inherited neurodegenerative disease characterized by motor, cognitive and psychiatric symptoms. As glutamate has been shown to be a potential biomarker of neurodegenerative diseases, we used Chemical Exchange Saturation Transfer imaging of glutamate (gluCEST) to map cerebral glutamate distribution in a rat model of HD. The longitudinal follow-up of brain glutamate levels reveals different variations between HD and control animals, suggesting that gluCEST may serve as a potential biomarker of HD, especially at asymptomatic stage.

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