Meeting Banner
Abstract #3214

Spectroscopy and sodium analysis of dissociated cellular therapy in acute ischemia at 21.1 T

Shannon Helsper1,2, F. Andrew Bagdasarian1,2, Xuegang Yuan2, Nastaren Abad1,2, Jens T. Rosenberg1, Teng Ma2, and Samuel Colles Grant1,2

1National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States

This study evaluates biochemical markers in a rat model of acute ischemia at 21.1 T following administration of human mesenchymal stem cells dissociated (d-hMSC) from 3D aggregates utilizing sodium (23Na) chemical shift imaging (CSI) and relaxation-enhanced MRS. High field 1H MRS provides sensitive longitudinal metabolic mapping of biological markers including lactate, NAA, creatine and choline in response to cellular treatment. Evaluation of 23Na CSI provides insight into cerebral ionic homeostasis and tissue recovery following acute neurodegeneration by tracking ischemic lesion volumetrics.

This abstract and the presentation materials are available to members only; a login is required.

Join Here