Abstract #3222

Preclinical detection of leptomeningeal inflammation in the myelin oligodendrocyte glycoprotein (MOG) induced experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS)

Zachary Smith¹, Nicola Bertolino¹, Suyog Pol¹, Marilena Preda^1,2, Michelle Sveinsson¹, Robert Zivadinov^1,2, and Ferdinand Schweser^1,2

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ²Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States

Clusters of inflammatory cells in the leptomeningeal compartment are suspected to contribute directly to subpial cortical demyelination and neurodegeneration in patients with multiple sclerosis (MS). Clinical post-contrast 3D T₂-FLAIR detects these clusters through the leakage of a T₁ contrast agent into inflammatory foci and the subarachnoid space, referred to as leptomeningeal contrast enhancement (LMCE). While leptomeningeal inflammation has been reported in rodent models of MS, LMCE has not been used to study disease pathology in the preclinical setting.

In this work, we present an imaging protocol for LMCE imaging in the experimental autoimmune encephalomyelitis myelin oligodendrocyte glycoprotein (EAE-MOG) murine model of MS at 9.4 Tesla.

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