Abstract #3223

Diffuse white matter disease revealed in novel rat model of cerebral amyloid angiopathy type 1 by multi-modality MRI at 9.4T.

Hedok Lee¹, Sunil Koundal¹, Xiaodan Liu¹, Feng Xu², Simon Sanggaard¹, William E. Van Nostrand², and Helene Benveniste¹

¹Department of Anesthesiology, Yale University, New Haven, CT, United States, ²Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, United States

A novel cerebral amyloid angiopathy type 1 rat model which robustly develops microvascular amyloid beta deposits is studied. We report that this animal model develops white matter atrophy, cerebral micro-bleed, and loss of white matter integrity. These findings are corroborated by immunohistochemistry showing axonal disruption and vacuolization.

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