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Abstract #3223

Diffuse white matter disease revealed in novel rat model of cerebral amyloid angiopathy type 1 by multi-modality MRI at 9.4T.

Hedok Lee1, Sunil Koundal1, Xiaodan Liu1, Feng Xu2, Simon Sanggaard1, William E. Van Nostrand2, and Helene Benveniste1

1Department of Anesthesiology, Yale University, New Haven, CT, United States, 2Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, United States

A novel cerebral amyloid angiopathy type 1 rat model which robustly develops microvascular amyloid beta deposits is studied. We report that this animal model develops white matter atrophy, cerebral micro-bleed, and loss of white matter integrity. These findings are corroborated by immunohistochemistry showing axonal disruption and vacuolization.

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